Gathering the record
Relay is organizing the evidence and source boundaries.
Dual GIP / GLP-1 receptor agonist
An experimental weight-loss drug being developed as both an injection and a tablet.
Evidence is explained by question. Dosing references show their own check dates.
60-second overview
Why people look into it, what studies found, and what is still unknown.
Educational information only. Evidence reviewed through July 31, 2026. Published studies, sponsor announcements, and trials without results are labeled separately. Evidence gaps apply to the specific finding beside them.
Research questions
Each label shows how much evidence supports that question.
What studies show
A peer-reviewed randomized 176-participant Phase 2 subcutaneous obesity trial, with additional sponsor-reported oral Phase 2 results and active large Phase 3 trials.
Its receptor class resembles tirzepatide, but it is a distinct investigational molecule with its own evidence record.
All active doses significantly reduced weight versus placebo, with the largest mean reduction reaching 14.7% from baseline.
Encouraging short-term tolerability does not establish long-term safety.
The sponsor reported up to 12.2% mean reduction at 13 weeks, pending fuller independent and peer-reviewed confirmation.
These trials should clarify durability, type 2 diabetes performance, and a broader safety profile.
Early high weight-loss percentages should not be converted into expected long-term personal results.
A tablet and an injectable require different absorption, stability, manufacturing, and quality controls.
Risks & unknowns
Most reported VENTURE adverse events were mild or moderate, with gastrointestinal events common.
Controlled human evidenceThe sample was modest and exposure lasted only 13 weeks.
Open sourceMost reported VENTURE adverse events were mild or moderate, with gastrointestinal events common.
Controlled human evidenceThe stated frequency is source-, product-, population-, route-, dose-, comparator-, and duration-specific; it is not a universal incidence estimate.
Open sourceRelay has not verified which side effects led people to stop treatment in studies.
Evidence boundaryThis is an evidence gap, not proof that discontinuations did not occur.
Relay has not verified a compound-specific warning summary for this profile.
Evidence boundaryInvestigational; subcutaneous Phase 3 and oral development Seventy-eight-week durability and safety, Phase 3 completion, cardiovascular outcomes, comparative efficacy, oral formulation confirmation, rare events, and weight maintenance.
This profile does not contain verified, product-specific emergency instructions.
Evidence boundaryRelay does not infer emergency guidance from study discontinuations, mechanism, or incomplete adverse-event reporting.
Dosing references
Each table labels its source and applies only to the named route, product, or study. An online example or community report is not an approved dose.
Amounts reported in a human study. A studied amount is not automatically an approved dose or a recommendation for an individual.
The 13-week Phase 2 trial enrolled adults with obesity or overweight.
| Stage / period | Amount in source | Frequency |
|---|---|---|
| 13 weeks | 2.5, 5, 10, or 15 mg targets | Once weekly |
Targets are not all starting doses. This reference does not reconstruct titration steps or transfer the injectable regimen to oral VK2735.
VK2735 · VENTURE randomized Phase 2 trial Primary article · Methods / interventionThis reference checked Oct 20, 2026. The full-profile review date is shown at the top.This source does not establish a mixing volume or storage period for independently sourced powder. Use formulation-specific instructions; the study amount alone is not a reconstitution recipe.
Concentration = total mass ÷ final volume. The calculator performs user-entered math; it does not choose a dose or diluent.
Open concentration calculatorStarting dose: the amount used at the beginning of the named label schedule or trial.
Maintenance: the ongoing amount described by that product label.
Trial target: the amount assigned to a study group. Different groups may stop increasing at different targets.
A peer-reviewed Phase 2 trial investigated the injectable form of VK2735 in adults with obesity over a short early efficacy period.
Population: Adults with obesity
Design: Randomized, double-blind, placebo-controlled dose-ranging trial
Mechanisms
VK2735 is a dual agonist at GIPR and GLP-1R. In the peer-reviewed 176-participant VENTURE Phase 2 trial, 13 weekly subcutaneous doses produced mean weight reductions up to 14.7% from baseline and up to 13.1 percentage points versus placebo, with no plateau observed during the short trial. Gastrointestinal events were common but mostly mild or moderate. A separate 13-week oral Phase 2 program later reported dose-dependent mean reductions up to 12.2%, but those results were sponsor-reported and not yet equivalent to a full peer-reviewed pivotal record. The VANQUISH-1 and VANQUISH-2 Phase 3 trials are evaluating weekly subcutaneous VK2735 for 78 weeks. No approval, long-term cardiovascular outcome, maintenance, or head-to-head comparative result exists.
A plausible mechanism can explain why a study was attempted. It does not prove that the compound improves a human outcome.
Research reference
A reference for the studies, populations, and routes behind this profile.
Peer-reviewed short Phase 2 injection evidence is joined by oral data and active 78-week Phase 3 trials.
Research depth describes how large and mature the overall record is. It does not tell you whether the results were positive.
The 13-week signal is controlled; durability, oral confirmation, outcomes, and rare events remain open.
Confidence describes how reliable and consistent the conclusions are. It can be high for one outcome and low for another.
The strongest evidence type shows what the best-supported conclusions are actually based on.
Human findings are more directly relevant than animal or laboratory results, but they still apply only to the populations and outcomes studied.
Route-specific record
These are exposures used in cited research for a specific route and population—not an instruction for an individual.
Half-life describes how long it takes the measured amount in the body to fall by half. It is not a dosing recommendation.
Evidence can change by administration method. Findings from one route should not automatically be applied to another.
Evidence boundary: Thirteen weeks is too short to establish durability, maintenance, uncommon harms, or cardiovascular outcomes. The injection findings cannot be transferred to the oral formulation or independently sourced material. Amounts shown describe cited research exposure—not a dosage recommendation.
Studies
Study arms are reported for transparency. They describe what researchers did in a defined record and do not transfer across identities, routes, formulations, or populations.
A later trial phase can ask a more mature question, but it does not guarantee a positive result, regulatory approval, or relevance outside the studied population.
Randomized, double-blind, placebo-controlled dose-ranging trial
Adults with obesity
Mean weight reduction reached 14.7% from baseline and 13.1 percentage points versus placebo at the highest studied response, with no plateau during 13 weeks.
Study administration: Once-weekly subcutaneous VK2735 dose groups or placebo
Limitations: Thirteen weeks is too short to establish durability, long-term tolerability, maintenance, or cardiovascular outcomes.
Randomized, double-blind, placebo-controlled dose-finding trial
Adults with obesity
The sponsor reported dose-dependent mean weight reductions up to 12.2% at 13 weeks.
Study administration: Once-daily oral VK2735 dose groups or placebo
Limitations: The result was sponsor-reported and had not matured into a peer-reviewed pivotal publication at the cutoff.
Randomized, double-blind, placebo-controlled 78-week trial
Adults with obesity or overweight plus a comorbidity
VANQUISH-1 is testing longer-term efficacy and safety in a much larger pivotal population.
Study administration: Once-weekly subcutaneous VK2735 dose groups or placebo
Limitations: No completed Phase 3 results were available.
Randomized, double-blind, placebo-controlled 78-week trial
Adults with obesity or overweight and type 2 diabetes
VANQUISH-2 is the dedicated pivotal test in type 2 diabetes.
Study administration: Once-weekly subcutaneous VK2735 dose groups or placebo
Limitations: No completed efficacy or safety results were available.
Randomized single- and multiple-ascending-dose study
Healthy adults with increased body mass index
Early studies supported prolonged subcutaneous exposure and dose-dependent weight signals for both formulations.
Study administration: Subcutaneous and oral VK2735 formulations or placebo
Limitations: Small early-phase cohorts and exploratory weight endpoints cannot establish clinical efficacy.
Community
Built by the community
Every structured report adds useful context about research setup, outcomes, and unwanted effects as the community dataset grows.
Publicly anonymous by default. Your account keeps reports editable and helps reduce duplicate submissions.Sources
2026-07-29
2026-05-12
2026-01-12 · PMID 41508550 · DOI 10.1002/oby.70106
2025-07-01 · NCT07104500
2025-07-01 · NCT07104383
2022-01-24 · NCT05203237