Gathering the record
Relay is organizing the evidence and source boundaries.
GHRH-analog family with distinct DAC and non-DAC active moieties
An experimental peptide that makes the body release growth hormone. Long-acting DAC and products called no-DAC need to be kept separate.
Evidence is explained by question. Dosing references show their own check dates.
60-second overview
Why people look into it, what studies found, and what is still unknown.
Educational information only. Evidence reviewed through July 25, 2026. Published studies, sponsor announcements, and trials without results are labeled separately. Evidence gaps apply to the specific finding beside them.
Research questions
Each label shows how much evidence supports that question.
What studies show
Two small randomized, placebo-controlled pharmacology studies in healthy adults found sustained GH and IGF-1 increases after CJC-1295 DAC exposure. They measured hormone responses, not meaningful health outcomes.
FDA evaluated five bulk substances across two active moieties: a non-DAC 29-amino-acid form and an albumin-binding DAC form, each with multiple possible salt identities.
The clearest human evidence is pharmacology: measured hormone concentrations increased after subcutaneous research administration.
FDA found that the published clinical references appear to involve the DAC active moiety, with salt identity unspecified.
The published human studies measured pharmacokinetics, GH, and IGF-1 in healthy adults. The registered visceral-obesity trial was terminated without posted results.
The PCAC votes addressed whether the evaluated bulk substances should be eligible for specified compounding conditions; they were not drug-approval decisions.
WADA includes GHRH analogues and related growth-hormone-releasing factors in the prohibited peptide-hormone category.
Risks & unknowns
Relay has not verified a clear pattern of side effects for this compound.
Evidence boundaryHuman exposure is present, but the record is not detailed enough to characterize a reliable adverse-event pattern.
The available information does not reliably show how often particular side effects occur.
Evidence boundaryUnder-detected or under-reported events must not be described as rare.
Relay has not verified which side effects led people to stop treatment in studies.
Evidence boundaryThis is an evidence gap, not proof that discontinuations did not occur.
Relay has not verified a compound-specific warning summary for this profile.
Evidence boundaryNot FDA approved. FDA distinguishes five CJC-1295-related bulk substances across two non-interchangeable active moieties; the 2024 PCAC voted against 503A Bulks List inclusion for the evaluated forms. Prohibited in sport under WADA S2. Clinical benefits, repeat-exposure and long-term safety, product identity across commonly conflated forms, and whether any findings apply to non-DAC/Mod GRF(1-29).
This profile does not contain verified, product-specific emergency instructions.
Evidence boundaryRelay does not infer emergency guidance from study discontinuations, mechanism, or incomplete adverse-event reporting.
Dosing references
Each table labels its source and applies only to the named route, product, or study. An online example or community report is not an approved dose.
Amounts reported in a human study. A studied amount is not automatically an approved dose or a recommendation for an individual.
The 2006 studies tested long-acting, albumin-binding CJC-1295 in healthy adults aged 21–61.
| Stage / period | Amount in source | Frequency |
|---|---|---|
| 28-day single-dose study follow-up | 30 or 60 micrograms/kg | Single-dose levels highlighted in the report |
These are selected studied levels, not every trial arm. The paper also included a separate multiple-dose study. Neither record establishes a dose for products called CJC-1295 without DAC or a CJC/ipamorelin blend.
CJC-1295 · randomized ascending-dose studies Abstract · Interventions and Conclusions; long-acting identity onlyThis reference checked Oct 20, 2026. The full-profile review date is shown at the top.This source does not establish a mixing volume or storage period for independently sourced powder. Use formulation-specific instructions; the study amount alone is not a reconstitution recipe.
Concentration = total mass ÷ final volume. The calculator performs user-entered math; it does not choose a dose or diluent.
Open concentration calculatorStarting dose: the amount used at the beginning of the named label schedule or trial.
Maintenance: the ongoing amount described by that product label.
Trial target: the amount assigned to a study group. Different groups may stop increasing at different targets.
Study or label pattern: Ascending study groups; not a fixed consumer sequence
Two short controlled studies evaluated long-acting CJC-1295 material in healthy adults to measure pharmacology, growth hormone, and IGF-1—not clinical benefit.
Population: Healthy adults aged 21–61
Design: Placebo-controlled, ascending-exposure human pharmacology studies
The direct human CJC-1295 evidence located for this pass concerns the long-acting DAC form and cannot be assigned to material marketed as “no DAC.”
Population: No directly verified human study population for this identity
Design: Identity and evidence-boundary review
Mechanisms
CJC-1295-related substances are 29-amino-acid GHRH analogues with substitutions intended to resist enzymatic degradation. The DAC active moiety adds a maleimidopropionamide-lysine group that binds circulating albumin and greatly extends exposure. FDA treats the non-DAC and DAC active moieties—and their free-base or salt forms—as distinct bulk drug substances. Published human pharmacology appears to involve CJC-1295 DAC free base with salt unspecified; those data should not be transferred to non-DAC or named salt forms.
A plausible mechanism can explain why a study was attempted. It does not prove that the compound improves a human outcome.
Research reference
A reference for the studies, populations, and routes behind this profile.
Small short-term studies measured GH, IGF-1, and pharmacokinetics for the DAC active moiety; clinical outcomes remain unestablished.
Research depth describes how large and mature the overall record is. It does not tell you whether the results were positive.
The DAC pharmacology signal is traceable, but promoted outcomes, long-term safety, and all no-DAC claims lack controlled human support.
Confidence describes how reliable and consistent the conclusions are. It can be high for one outcome and low for another.
The strongest evidence type shows what the best-supported conclusions are actually based on.
Human findings are more directly relevant than animal or laboratory results, but they still apply only to the populations and outcomes studied.
Route-specific record
These are exposures used in cited research for a specific route and population—not an instruction for an individual.
Half-life describes how long it takes the measured amount in the body to fall by half. It is not a dosing recommendation.
Evidence can change by administration method. Findings from one route should not automatically be applied to another.
Evidence boundary: The studies measured hormone pharmacology in healthy adults and did not test body composition, recovery, sleep, or anti-aging outcomes. Weight-based study exposure must not be converted into a fixed amount or schedule. Amounts shown describe cited research exposure—not a dosage recommendation.
Studies
Study arms are reported for transparency. They describe what researchers did in a defined record and do not transfer across identities, routes, formulations, or populations.
A later trial phase can ask a more mature question, but it does not guarantee a positive result, regulatory approval, or relevance outside the studied population.
Two randomized, double-blind, placebo-controlled, ascending-dose studies
Healthy adults aged 21–61 years
A single injection produced dose-dependent increases in mean GH for at least six days and IGF-1 for about 9–11 days. Repeated exposure kept mean IGF-1 above baseline for up to 28 days.
Study administration: Subcutaneous CJC-1295 DAC of unspecified salt at single or repeated study doses; these were research arms, not dosing guidance
Limitations: Small, short studies in healthy adults measured hormones rather than clinical outcomes. FDA concluded the active moiety appears to have been the DAC form, with the salt unspecified; the results should not be assigned to non-DAC or named salt forms.
Intensive 24-hour growth-hormone sampling after one subcutaneous administration
Healthy adult men
Mean and trough GH and IGF-1 increased while measurable pulsatile GH secretion persisted.
Study administration: Single subcutaneous CJC-1295 DAC administration under the research protocol
Limitations: Very small study without a separate clinical-outcome endpoint. It demonstrates a hormone pattern, not improved recovery, sleep, body composition, or health.
Randomized, double-blind, placebo-controlled trial with weekly low-dose and high-dose groups
Adults with HIV-associated visceral obesity
No results are posted. Development stopped after a participant experienced a fatal myocardial infarction during the trial.
Study administration: Weekly subcutaneous CJC-1295 or placebo under the registered protocol
Limitations: The registry does not establish causality. FDA reports that the attending physician attributed the event to underlying coronary disease and plaque rupture, while formal trial results were not published. A terminated registration cannot demonstrate efficacy or safety.
Community
Built by the community
Every structured report adds useful context about research setup, outcomes, and unwanted effects as the community dataset grows.
Publicly anonymous by default. Your account keeps reports editable and helps reduce duplicate submissions.Sources
2026-07-31
2026-01-01
2024-12-04
2024-11-15
2006-12-01 · PMID 17018654 · DOI 10.1210/jc.2006-1702
2006-03-01 · PMID 16352683 · DOI 10.1210/jc.2005-1536
2005-12-23 · NCT00267527